Background: Among various natural therapeutic remedies, Aloe vera, a medical plant widely used in food supplements, beverages, pharmaceutical and cosmetics. Aloe vera has been widely reported for its numerous medicinal effects. Objectives: The present investigation was carried out to study the histological changes in the mice testis consumed low doses of Aloe vera leaf gel extracts. Methods: Forty immature male Swiss Webster mice divided into two equal groups (experimental and control) (G and C respectively). The experimental group (G) was given 10 µl of Aloe vera extract orally for 21 days. While the control groups (C) were given by the same dose and rout of administration with normal saline only. After Six weeks (around puberty) the male were sacrificed to get their testes; each testis was fixed. Then histological sections with a thickness of 5 microns were prepared. Results: Histological studies of mice testes from groups that consume low dose Aloe vera extracts showed enhanced the entire structure of spermatogenic layer of semineferous tubules that composed of extensive normal arranged germ cells layer. A significant increase in the numbers of spermatogonia, primary spermatocytes and spermatids, rates of normal supporting (Sertoli cells) and Leydig's cells. A significant increase in the rate of height of epithelial cells, and rates of sperms concentration in the semineferous tubules were observed too. Conclusion: Using low dose of Aloe vera extract enhanced the histological structure of male mice testis and may be useful to produce drugs to improve male fertility.