Cover
Vol. 4 No. 1 (2014)

Published: July 31, 2014

Pages: 33-36

Research Article

Correlation between Obesity and Semen Interleukin-6 with Sperm Concentration and Motility in Iraqi infertile Men

Rehab Al Maliki 1 Mohammad O. Selman Thaer M. Farhan 2 Anam Al Salihi 1
1High Institute for Infertility Diagnosis and ART/ Al-Nahrain University, Baghdad, Iraq
2College of Medicine, AL-Nahrain University
History
  • Received: April 1, 2014
  • Available Online: July 1, 2014

Abstract

Background: Obesity has been defined as abnormal or excessive fat accumulation that may impair health while the Body mass index (BMI) is a simple index of the weight-to-height ratio that is commonly used in classifying overweight and obesity in adult populations. Many semen parameters alteration can be ascribed to obesity like decreased sperm concentration, abnormal morphology, compromised chromatin integrity and abnormal motility. Many evidences showed an adverse effect of excess body fat on spermatogenesis. Methods: A total sample size composed of (70)infertile men were grouped into three groups according to published BMI ranges as follows: normal weight, overweight and obese.A single semen sample was collected for each infertile men.Heightin (m) and weight in (kg) were recorded on day of semen collection.BMI was calculated as BMI= Kg\m2. Sperm parameters evaluated according to World Health Organization guidelines.Quantitation of the IL-6 in seminal plasma were accomplished using commercially available ELISA kit. Results: In the current study, a positive correlation was found between body mass index and IL-6, on the contrary, a significant negative correlation was found among IL-6 level and progressive sperm motility and sperm concentration as well. Conclusion: There is an increase of IL-6 from the adipose tissue with increasing BMI. The IL-6 cause reduction of the sperm motility by increasing the level of ROS. The obesity reduces the spermatogenesis by androgenic deficiency results in low sperm concentration and motilitywhich it may be the main reason of their infertility.

Keywords

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