Monosodium Glutamate (MSG) is the sodium salt of glutamate (simply glutamate, water and sodium) and is widely used as food additive and as flavoring agent to increase appetite. The present study was to evaluate the effect of daily oral admiration of (MSG) (100mg/kg/day) for 30day on reproductive system of males and females Swiss albino mice. Forty albino mice weighting about (25-30kg) were used in the present study. The animal were divided in two groups: control group (10 males and 10 females)(n=20) and treated group(males and females) n=20.The body weight of the animals detected at the beginning and the end of experiment. At 30 days animals sacrificed and ovaries, uterus, testis were removed and weighted, Samples of ovaries, uterus testis fixed in 10%formaline for histological study. The final result show highly significant increase in the body weight and show significant decrease in the weight of ovaries and testis. The histological study in the treated group of testis show suppression of spermatogenesis, degenerate of seminiferous tubules and congestion of blood vessels. The histological changes in the ovaries such as congested blood vessels of medulla, increased atretic follicles and uterus show necrosis in perimetrium , presence of lacunae in the uterine wall structure . Conclusions: Monosodium glutamate has negative effect on reproductive system for each sex. So that will effect on the fertility .Also the increased body weight could lead to increase the incidence of congestive heart diseases and diabetes mellitus.
Monosodium glutamate (MSG) is a widely used flavor enhancer in many foods. However, excessive consumption during pregnancy may adversely affect embryonic development and reproductive functions. This study aimed to investigate the effects of maternal MSG consumption during pregnancy on pregnancy outcomes and the reproductive system of female offspring in mice. Thirty adult pregnant female mice, aged 42–49 days, were used in this study. The animals were equally divided into two groups: an experimental group (G1) and a control group (G2). The experimental group received MSG extract orally at a dose of 1 mg/kg body weight dissolved in 1 ml of distilled water (D.W.) throughout the three weeks of pregnancy, whereas the control group received 1 ml of distilled water alone for the same duration. After delivery, litter size and litter weight were recorded. Forty days after birth, the weights of the female reproductive organs were measured, and the diameters of the ovaries and oviducts were assessed. In addition, blood samples were collected for the evaluation of follicle-stimulating hormone (FSH), luteinizing hormone (LH), and estradiol (E2) levels in both groups. The experimental group showed a significant reduction in litter size and a significant decrease in litter weight compared with the control group. Female offspring born to MSG- treated mothers also exhibited a significant decrease in reproductive organ weight, ovarian diameter, and oviduct diameter. Furthermore, significant reductions in the levels of FSH, LH, and estradiol were observed in the experimental group. Maternal consumption of MSG during pregnancy may negatively affect pregnancy outcomes and impair the development and function of the reproductive system in female offspring.