Cover
Vol. 7 No. 1 (2017)

Published: July 31, 2017

Pages: 7-16

Research Article

Histological and Hormonal Study on Effect of Clomiphene Citrate (CC) on Some Reproductive and Embryonic Parameters in Female Mice

Sally Adnan AL-Rekabi 1
1Middle Technical University, Institute of technical ,Wasit-IRAQ
History
  • Received: April 1, 2017
  • Available Online: July 1, 2017

Abstract

In present study, it was investigated the effect of clomiphene citrate on the ovaries reproductive hormones and embryos of mature female mice, were studied. Female mice treated with (5, 10,50 mg/kg ) daily for 7 days. Results cleared that cross section showed a significant increase (p<0.05) in multi follicular (different numbers )on the right and left ovaries of female mice. In other hand; there were a significant elevation (p<0.05) in the follicle stimulation hormone(FSH), estrogens and progesterone concentration, while, no significant changes were noticed in luteinizing (LH). Conclusions: Clomiphene citrate is the best initial treatment especially in relevance with ovulatory problems (dysfunction), and has a super stimulatory effect on ovulation, thereby increasing the number of recruited follicles in albino female mice rather than affecting the follicular steroidogenic function, and its induce multi follicle ovum forming. Similarly, it has positive affection on gonadotropene hormones, eventually it leads to a twin pregnancy. Combined c with appropriately timed IUI, Clomiphene citrate treatment also increases cycle fecundity in couples with unexplained infertility.

Keywords

References

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