Cover
Vol. 6 No. 1 (2016)

Published: June 30, 2016

Pages: 22-31

Research Article

Estimation of Aromatase Enzyme in Obese Infertile Men

Ula M. AL-Kawaz 1 Nawal K. AL-Ani 2 Hikmat F. Wassef 3
1Department of Clinical Reproductive Physiology-High Institute of Infertility Diagnosis and Assisted Reproductive Technologies-Al-Nahrain University-Baghdad, IRAQ
2College of Pharmacy-Al-Nahrain University-Baghdad, IRAQ
3Department of Applied Embryology-High Institute of Infertility Diagnosis and Assisted Reproductive Technologies-Al-Nahrain University-Baghdad, IRAQ
History
  • Received: March 1, 2016
  • Available Online: June 1, 2016

Abstract

Background: Male obesity is associated with physiological changes that can negatively affect male fertility. Obese men have demonstrated a 3-fold increase in the prevalence of oligozoospermia when compared with men with normal Body Mass Index (BMI). Objective: To estimate the role of aromatase enzyme in decreasing sperm parameters in obese infertile men. Subjects, Materials and Methods: Seventy obese infertile male (patients) and twenty obese fertile male (control) are enrolled in this study. Seminal fluid analysis done according to criteria of WHO (2010). Results: A significant negative correlation was found between human cytochrome enzyme and sperm concentration, progressively motile sperm, non-progressively motile sperm, immotile sperm and normal morphology. Conclusion: The present study showed clearly that male obesity negatively impacts fertility through direct association between increased (BMI) and semen parameters. The results suggest that increased estrogen as a result of aromatization in the fatty tissue, reflected through the increase in human cytochrome enzyme (aromatase), may be an important mechanism for the hypoandrogenemia and altered sperm parameters.

Keywords

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