Cover
Vol. 5 No. 1 (2015)

Published: June 30, 2015

Pages: 9-13

Research Article

The Effect of Pregabalin (Lyrica) on the Spermatogenic Cells in Rat

Ahmed M. Al-Zubaidi 1 Anam R. Al-Salihi 2 Saad S. Al-Dujaily 3
1Department of Applied Embryology-High Institute of Infertility Diagnosis and Assisted Reproductive Technologies-Al-Nahrain University-Baghdad, IRAQ
2Department of Human Anatomy-College of Medicine-Al-Nahrain University-Baghdad, IRAQ
3Department of Clinical Reproductive Physiology-High Institute of Infertility Diagnosis and Assisted Reproductive Technologies-Al- Nahrain University-Baghdad, IRAQ
History
  • Received: March 1, 2015
  • Available Online: June 1, 2015

Abstract

Background: Pregabalin is an anti-convulsent drug that is indicated in epilepsy, neuropathic pain and anxiety. This study evaluates its effect on spermatogenesis in male rats through histological and physiological examination of the seminiferous tubules. Two doses of Pregabalin were employed, 300, 600 mg/Kg B.Wt. given orally and daily to groups of 30 male albino rats ( Rattaus rattus) for 35 days. The changes in the testes were evaluated by paraffin sections stained with Hematoxylin and Eosin. The results showed relative preponderance of primitive germ cells over other stages of more mature spermatogenic cells. There was reduction in the diameter of the seminiferous tubule. These findings were more prominent with increase of the dose of Pregabalin. The above results were discussed in dose related context indicating that the current therapeutic dose of Pregabalin seems to not be within the range of dosage of Pregabalin that adversely affects spermatogenesis.

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