Cover
Vol. 12 No. 1 (2022)

Published: June 30, 2022

Pages: 55-67

Research Article

The effect of in vitro exposure to certain metformin doses on the motility of human spermatozoa.

Fatima Emad Al-Nashme 1 Wasan Adnan Al-Jubory
1High Institute for Infertility Diagnosis and Assisted Reproductive Technologies, Al-Nahrain University, Baghdad, Iraq.
History
  • Received: May 7, 2022
  • Accepted: May 30, 2022
  • Available Online: June 12, 2022
DOI

https://doi.org/10.28969/IJEIR.v12.i1.r5.22

Abstract

Metformin is an anti-hyperglycemic medication used to treat type 2 diabetes mellitus. Regardless of its anti-diabetic effect, metformin has a non-genomic action and it could be a beneficial additive to treat the sperm which considered as transcriptionally dormant cell and also a molecule that could rapidly adjust the metabolism of spermatozoa to adapt it to the surrounding environment. Sixty-four normozoospermic semen sample included in the study. Each sample incubated for 30 minutes with metformin (2.5 and 0.5 µM) and SFA was conducted to each sample. There was a significant decrease in total motility (progressive and non-progressive) in samples incubated with both concentrations compared with the neat samples. While the samples incubated with 0.5 µM shows a lower motility compared with 2.5 µM. Metformin significantly reduced total motility of fresh spermatozoa at both concentrations.

Keywords

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