Cover
Vol. 10 No. 2 (2020)

Published: August 31, 2020

Pages: 91-106

Research Article

Effect of BMI on chemerin in serum on females Undergoing ICSI.

Tawadud E. Kadhim 1 Muayad S. Abbood
1High Institute of Infertility Diagnosis and Assisted Reproductive Technologies, Al Nahrain University, Baghdad, Iraq.
History
  • Received: July 7, 2020
  • Accepted: July 30, 2020
  • Available Online: August 8, 2020
DOI

https://doi.org/10.28969/IJEIR.v10.i2.r6.20

Abstract

Serum chemerin levels are associated with body fat percentage and BMI, and elevated chemerin levels are associated with metabolic problems and inflammatory shifts. This study aimed to evaluate the effect of BMI in serum and follicular fluid chemerin and Leptin levels on patients undergoing ICSI . This study was performed by 44 women who underwent ICSI procedures and divided into two groups based on BMI: the non-obese group, with a BMI<30 and the obese group, with a BMI>30. The result in the non-obese group showed a significant positive correlation was found between Serum chemerin levels, indicating a strong effect size (p< .001). This suggests that as Serum chemerin levels rise, so will FF chemerin. A significant positive correlation of r =0.92 was found between the oocytes retrieved and the Number of metaphases II, indicating a strong effect size (p<.001, This shows that the number of metaphase II oocytes increases as the number of retrieved oocytes increases. A significant positive correlation of 0.66 was found between the number of embryos and the G1 embryo, indicating a large effect size. Conclusion: Serum chemerin had a significant correlation with oocyte maturity and embryo grading, and there was no significant difference between obese and non-obese patients regarding serum chemerin pregnancy.

Keywords

References

  1. Zivari‐Ghader, T., Dolati, S., Mehdizadeh, A., Davaran, S., Rashidi, M. and Yousefi, M., 2022. Recent scaffold‐based tissue engineering approaches in premature ovarian failure treatment. Journal of Tissue Engineering and Regenerative Medicine, 16 (7), pp.605-620 .
  2. Ghaffari, F. and Arabipoo, A., 2018. The role of conception type in the definition of primary and secondary infertility. International Journal of Reproductive BioMedicine, 16 (5), pp.355-356.
  3. Fischer, T. and Beck-Sickinger, A., 2022. Chemerin – exploring a versatile adipokine. Biological Chemistry, 12 ( 4 .)
  4. Marti, A., Martínez, I., Ojeda-Rodríguez, A. and Azcona-Sanjulian, M., 2021. Higher Lipopolysaccharide Binding Protein and Chemerin Concentrations Were Associated with Metabolic Syndrome Features in Pediatric Subjects with Abdominal Obesity during a Lifestyle Intervention. Nutrients, 13 (2), p.289 .
  5. Gambineri, A., Laudisio, D., Marocco, C., Radellini, S., Colao, A. and Savastano, S., 2019. Female infertility: which role for obesity? International Journal of Obesity Supplements, 9 (1), pp.65-72.
  6. Jaswa, E., McCulloch, C., Simbulan, R., Cedars, M. and Rosen, M., 2021. Diminished ovarian reserve is associated with reduced euploid rates via preimplantation genetic testing for aneuploidy independently from age: evidence for concomitant reduction in oocyte quality with quantity. Fertility and Sterility, 115 (4), pp.966-973.
  7. ULRICH, N. and MARSH, E., 2019. Ovarian Reserve Testing: A Review of the Options, Their Applications, and Their Limitations. Clinical Obstetrics & Gynecology, 62 (2), pp.228-237.
  8. Alfahl, S., Salamah, R., Saad, B., Saud, B., Mosallam, J., Khalaf, A. and Tariq, H., 2020. Awareness of polycystic ovarian syndrome among women of reproductive age in Al- Madinah Al-Munawarah, Saudi Arabia. International Journal of Medicine in Developing Countries, pp.1823-1830.
  9. Toosy, S., Sodi, R. and Pappachan, J., 2018. Lean polycystic ovary syndrome (PCOS): an evidence-based practical approach. Journal of Diabetes & Metabolic Disorders, 17 (2), pp.277-285 .
  10. Glueck, C. and Goldenberg, N., 2019. Characteristics of obesity in polycystic ovary syndrome: Etiology, treatment, and genetics. Metabolism, 92, pp.108-120.
  11. Xu, H., Shi, L., Feng, G., Xiao, Z., Chen, L., Li, R. and Qiao, J., 2020. An Ovarian Reserve Assessment Model Based on Anti- Müllerian Hormone Levels, Follicle- Stimulating Hormone Levels, and Age: Retrospective Cohort Study. Journal of Medical Internet Research, 22 (9), p.e19096 .
  12. Siddiqui, Q., Anjum, S., Zahra, F. and Yousuf, S., 2019. Ovarian reserve parameters and response to controlled ovarian stimulation in infertile patients. Pakistan Journal of Medical Sciences, 35 ( 4 .)
  13. Yang Yu-Lian, Liu Li-Ming, Deng Qing- Xue, Jia Xin-Hong, Liang Wen-Yan, Jiang Li, Song Wei-Jie and Mou Xing-Yang, 2022. Impacts of nonlinear effects on forward stimulated Brillouin scattering distributed sensing. Acta Physica Sinica, 0 (0), p.0 .
  14. Jiao, X., Meng, T., Zhai, Y., Zhao, L., Luo, W., Liu, P. and Qin, Y., 2021. Ovarian Reserve Markers in Premature Ovarian Insufficiency: Within Different Clinical Stages and Different Etiologies. Frontiers in Endocrinology, 12.
  15. Neha Singh, Nupur Hooja, Alka Batar, Aditi Jaiswal and Pooja Bairwa, 2022. A study of central fat accumulation indices amongst different polycystic ovary syndrome phenotypes. International Journal of Science and Research Archive, 6 (1), pp.284-287 .
  16. Niklowitz, P., Rothermel, J., Lass, N., Barth, A. and Reinehr, T., 2019. Is there a link between progranulin, obesity, and parameters of the metabolic syndrome in children? Findings from a longitudinal intervention study. Pediatric Diabetes, 20 (8), pp.1047- 1055.
  17. Ashtary-Larky, D., Lamuchi-Deli, N., Kashkooli, S., Mombaini, D., Alipour, M., Khodadadi, F., Bagheri, R., Dutheil, F. and Wong, A., 2021. The effects of exercise training on serum concentrations of chemerin in individuals with overweight and obesity: a systematic review, meta-analysis, and meta- regression of 43 clinical trials. Archives of Physiology and Biochemistry, pp.1-16.