Cover
Vol. 10 No. 2 (2020)

Published: August 31, 2020

Pages: 14-24

Research Article

Effects of Activin A Hormone on Fertilization Capacity of PCOS Women Undergoing ICSI Cycle in Sample of Iraqi Women .

Ghofran Khalial 1 Wasan Adnan Saad S. Al-Dujaily
1High Institute of Infertility Diagnosis and Assisted Reproductive Technologies, Al Nahrain University, Baghdad, Iraq.
History
  • Received: July 7, 2020
  • Accepted: July 30, 2020
  • Available Online: August 8, 2020
DOI

https://doi.org/10.28969/IJEIR.v10.i2.r2.20

Abstract

Activin is a member of the transforming growth factor-beta superfamily and is a polypeptide growth factor. Activin regulates follicle growth, gonadotropin responsiveness, steroidogenesis, oocyte maturation, ovulation, and corpus luteum function in the ovary via a local autocrine/paracrine effect. Activin measurement A level in serum and follicular fluid during the preovulatory stage in PCOS women undergoing an IVF/ICSI cycle to predict fertilization capacity earlier Fifty infertile couples, 25 with PCOS and 25 without PCOS, who attended Al Nahrain University in Baghdad, Iraq's High Institute of Infertility Diagnosis and Assisted Reproductive Technologies. The females that participated were between the ages of 18 and 40. On the day of oocyte retrieval, the level of Activin A in serum and follicular fluid was measured. Activin A levels in PCOS women's serum (activin A=1274 77.9) and follicular fluid (activin A =1038 50.3) compared to non-PCOS women's serum (activin A=453 25.74) and follicular fluid (Activin A=450 23.73). The study shows no correlation between activin A hormone with oocytes characteristics and fertilization rate in PCOS women with a significant increase of activin A hormone in the serum and FF of PCOS women compared to non PCOS women. Activin A level can predict a diagnosis of PCOS in addition to positive predictive pregnancy but not indicator of fertilization capacity in PCOS women.

Keywords

References

  1. Duffy, J. M. N., Bhattacharya, S., Bhattacharya, S., Bofill, M., Collura, B., Curtis, C. (2020). Standardizing definitions and reporting guidelines for the infertility core outcome set: an international consensus development study. Human Reproduction, 35 (12), 2735-2745.
  2. Escobar-Morreale, H. F. (2018). Polycystic ovary syndrome: definition, aetiology, diagnosis, and treatment. Nature Reviews Endocrinology, 14 (5), 270-284.
  3. Coticchio, G., Mignini Renzini, M., Novara, P. V., Lain, M., De Ponti, E., Turchi, D, Canto, M. (2018). Focused time-lapse analysis reveals novel aspects of human fertilization and suggests new parameters of embryo viability. Human Reproduction, 33 (1), 23-31.
  4. Ando, H. (2020). Activin. In Handbook of Hormones. Academic Press. pp. 559-562.
  5. Faramarzi, A., Khalili, M. A., Agha- Rahimi, A., & Omidi, M. (2017). Is there any correlation between oocyte polarization microscopy findings with embryo time-lapse monitoring in the ICSI Program? Archives of gynecology and obstetrics, 295 (6), 1515- 1522.
  6. Cronk, B. C. (2019). How to use SPSS®: A step-by-step guide to analysis and interpretation. Routledge.
  7. Ranjzad, F., Mahban, A., Shemirani, A. I., Mahmoudi, T., Vahedi, M., Nikzamir, A., & Zali, M. R. (2011). Influence of gene variants related to calcium homeostasis on biochemical parameters of women with polycystic ovary syndrome. Journal of Assisted Reproduction and Genetics, 28 (3), 225-232
  8. Kumar R, Gautam G, Gupta NP. Drug Therapy for Idiopathic Male Infertility : Rationale Versus Evidence. 2006;176 (October):1307–12 .
  9. Altun, T., Jindal, S., Greenseid, K., Shu, J., & Pal, L. (2011). Low follicular fluid IL-6 levels in IVF patients are associated with an increased likelihood of clinical pregnancy. Journal of Assisted Reproduction and Genetics, 28 (3), 245-251. .
  10. Nikbakht, R., Mohammadjafari, R., Rajabalipour, M., & Moghadam, M. T. (2020). Evaluation of oocyte quality in Polycystic ovary syndrome patients undergoing ART cycles. Fertility Research and Practice, 7 (1), 1-6.
  11. Al-Dujaily, S. S., & Shukry, N. T. (2019). Role of Serum Activin A and Granulocyte Macrophage-Colony Stimulating Factor in the Prediction of Pregnancy Outcome in PCOS and Non-PCOS Women Following ICSI. Indian Journal of Public Health Research & Development, 10 (9).
  12. Rajani, S., Chattopadhyay, R., Goswami, S. K., Ghosh, S., Sharma, S., & Chakravarty, B. (2012). Assessment of oocyte quality in polycystic ovarian syndrome and endometriosis by spindle imaging and reactive oxygen species levels in follicular fluid and its relationship with IVF-ET outcome. Journal of Human Reproductive Sciences, 5 (2), 187.
  13. Sigala, J., Sifer, C., Dewailly, D., Robin, G., Bruyneel, A., Ramdane, N., ... & Decanter, C. (2015). Is polycystic ovarian morphology related to poor oocyte quality after controlled ovarian hyperstimulation for intracytoplasmic sperm injection? Results from a prospective, comparative study. Fertility and Sterility, 103 (1), 112-118.
  14. Qiao, J. & Feng, H. L. (2011). Extra-and intra-ovarian factors in polycystic ovary syndrome: impact on oocyte maturation and embryo developmental competence. Human Reproduction Update, 17 (1), 17-33
  15. Puttabyatappa, M., & Padmanabhan, V. (2018). Ovarian and extra-ovarian mediators in the development of polycystic ovary syndrome. Journal of Molecular Endocrinology, 61 (4), R161-R184.