Cover
Vol. 10 No. 1 (2020)

Published: December 31, 2020

Pages: 51-66

Research Article

Glycotoxins Relationship with Body Mass Index (BMI)

Aseel Abd Ali Yousif 1 Mufeda Ali Jwad Nadia Al-Hilli 2
1High Institute of Infertility Diagnosis and Assisted Reproductive Technologies, Al Nahrain University, Baghdad, Iraq.
2Department of Obstetrics & Gynecology, College of Medicine, University of Babylon, Babylon, Iraq .
History
  • Received: April 19, 2020
  • Accepted: July 12, 2020
  • Available Online: December 16, 2020
DOI

https://doi.org/10.28969/IJEIR.v10.i1.r4

Abstract

Glycotoxins termed as advanced glycation endproducts (AGEs) are made endogenously and exogenously. Maillard reaction is a chemical non-enzymatic process, between sugars and a free amino acid group of nucleic acids, proteins, and lipids which happens exogenously when handled with high temperature for a prolonged period and in a dry environment, resulting in glycotoxins (AGEs) formations. This reaction is responsible for the taste, color, and smell of food. Glycotoxins derived from food are absorbed in the intestine and store in cells and tissues. Also, glycotoxins are derived exogenously from smoking. While endogenous glycotoxins are generated by normal body physiology. Obesity and insulin resistance may induce glycotoxins (AGEs) accumulation. The objective of this study was to evaluate the relationship between glycotoxins (AGEs) and obesity. 66 infertile females who were undergoing intracytoplasmic sperm injection ICSI. These females were classified into three groups according to their body mass index. On the day of ova pick up the collect serum and follicular fluid for subsequent measurement of glycotoxins (AGEs) by ELISA kits. there was a significant difference in the concentration of glycotoxins in follicular fluid and serum between the three ICSI groups of patients. As well as there was a significant difference in the concentration of glycotoxins (AGEs) in follicular fluid and serum in the same ICSI groups of patients. there is a significant positive relation between glycotoxins (AGEs) and increase BMI.

Keywords

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