Cover
Vol. 9 No. 2 (2019)

Published: December 31, 2019

Pages: 95-108

Research Article

Effect of Endometrial Scratch on Heparin Binding Epidermal Growth Factor Level in Women Undergoing Intrauterine Insemination

Ekhlas D. Blawa 1 Manal T.AL-Obaidi Wasan A. Abdulhameed
1High Institute of Infertility Diagnosis and Assisted Reproductive Technologies, Al-Nahrain University, Baghdad, Iraq
History
  • Received: November 10, 2019
  • Accepted: May 1, 2020
  • Available Online: May 22, 2020
DOI

https://doi.org/10.28969/IJEIR.v9.i2.r7

Abstract

Despite many improvements in Assisted reproductive techniques during the last three decades, clinical pregnancy and live-birth rates still nearly 30–40% and 20–30%, respectively. To enhance endometrial receptivity many attempts done one of the endometrial scratching could provoke delay in endometrial maturation reforms asynchrony between endometrium and the concepts and indeed induce wound healing by producing a considerable raise in the local secretion of pro-inflammatory cytokines and growth factors like Heparin Binding Epidermal Growth Factor (HBEGF) and its receptors has role in mediate the receptivity, maturation, and decidualization of endometrium and facilitates the implantation and development of both placenta and embryo. All women were undergone IUI procedure. They divided into two groups. Intervention group who did endometrial scratching by using pipelle catheter in luteal phase of preceding cycle and another blood sample aspirated before scratch. Control group include women without intervention of endometrial scratch. Both groups underwent controlled ovarian stimulation, triggering of ovulation and another blood sample was aspirated at day of IUI to measure level of HBEGF. 14 days later with luteal support, BHCG test underwent in blood to check pregnancy. Higher pregnancy rate among patients with scratch group (5/20) 25% than non-interventional group (3/25)12%. These result showed that HBEGF level in scratch group (386.1±124.7) is significantly higher than control group (279±189.3) as P-value was (0.035). Moreover, the HBEGF level at day of IUI (455.67±157.34) and in pregnant (563.9±163.66) is significantly higher than before scratch in scratch group (279.0±124.67), (406.26±138.89), as P-values were (0.00007, 0.049) respectively. Intentional local damage to the endometrium is a cost–effective procedure can be used to enhance the uterine receptivity that may help to overcome implantation failure problem.

Keywords

References

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  26. Karimzadeh MA, Ayazi Rozbahani M, Tabibnejad N. Endometrial local injury improves the pregnancy rate among recurrent implantation failure patients undergoingin vitrofertilisation/intra cytoplasmic sperm injection: A randomised clinical trial. Australian and New Zealand Journal of Obstetrics and Gynaecology. Wiley; 2009;49(6):677– 80. Doi: http://dx.doi.org/10.1111/j.1479- 828x.2009.01076.x [PubMed][Wiley] Biography Dr. Ekhlas D. Blawa She graduated from the University of Baghdad college of medicine in 1999. She Senior house officer in Al Habbibia hospital 2001 Permanent resident in Gynecology and obstetrics In Al-Elwyia hospital 2010-2016. Graduated as a senior in Obstetrics and Gynecology from 2016 till now Diploma in ART and infertility from the high institute of infertility diagnosis in Assisted Reproductive Technology in 2020, Al Nahrain University. Dr. Manal Taha Meteab Al- Obaidi She received the M.B.CH.B. from Al-Mustansirya University, the High diploma (equivalent to MSc.) in Assisted Reproductive Technology, Ph.D. in reproductive physiology in 1997, 2003, and 2013 respectively. She occupied several academic positions including the head of the clinical reproductive physiology department and currently, she is the dean of the High Institute of Infertility Diagnosis and Assisted Reproductive Technologies, Al Nahrain University. She published more than 20 articles both local and international. Dr. Wasan A. Abdulhameed She received M.B.CH.B. from the University of Baghdad, College of medicine in 1992, the diploma and the Arab Board in Gyn.&Obs from Medical City, Baghdad in 1998. She worked in Al Sharjah University, UAE. She earned the laparoscopic surgery certificate from India in 2009. She was a Lactation consultant in Australia in 2010. She occupied many administrative positions She attended more than 20 academic congresses internationally. How to cite: Blawa ED, Al-Obaidi MT, Abdulhameed WA. Effect of Endometrial Scratch on Heparin Binding Epidermal Growth Factor Level in Women Undergoing Intrauterine Insemination; Iraqi Journal of Embryos and Infertility Researches (IJEIR), (2019); 9(2): 95-108. Doi: http://doi.org/10.28969/IJEIR.v9.i2.r7 © 2019 Author(s)