Cover
Vol. 9 No. 2 (2019)

Published: December 31, 2019

Pages: 78-94

Research Article

Using Uterine Biophysical Profile as a Predictor of Endometrial Receptivity and Pregnancy in Stimulated IUI Cycles

Rawaa Saad Hasan Abunayla 1 Lubna Amer Al-Anbari Muayad S. Abood Huda A. R. Hussaini
1High Institute of Infertility Diagnosis and Assisted Reproductive Technologies, Al Nahrain University, Baghdad, Iraq
History
  • Received: November 10, 2019
  • Accepted: May 16, 2020
  • Available Online: May 17, 2020
DOI

https://doi.org/10.28969/IJEIR.v9.i2.r6

Abstract

Implantation failure and disorders of endometrial receptivity represent an essential cause of infertility; multiple parameters were needed to predict the uterine receptivity understanding that no sole parameter could predict the same. A score was termed as (Uterine Biophysical Profile) could be utilized as a predictor of endometrial receptivity. To evaluate the predictive potential of Uterine biophysical profile of both endometrial receptivity and pregnancy outcome in infertile women undergoing Intrauterine Insemination (IUI). The current cross-sectional study was conducted in the High Institute for Infertility Diagnosis and Assisted Reproductive Technologies in Al Nahrain University, Baghdad, Iraq from the 1 st of Oct. 2018 till 1 st of May 2019 involving seventy women of infertile couples with the same inclusion and exclusion criteria. Uterine biophysical profile was evaluated using a doppler ultrasound examination and then a score was calculated and correlated to pregnancy outcome. The mean Uterine Artery Pulsatility Index (UAPI) was significantly lower in women with positive pregnancy in comparison to women with negative pregnancy, 2.10±0.19 versus 2.47±0.65, respectively (P=0.032). Moreover, no women with Pulsatility Index (PI) score (0) succeeded to get pregnant and the higher the score, the higher the rate of pregnancy (P=0.006). Furthermore, Spearman correlation showed significant positive correlation between positive pregnancy outcome and UAPI (r=0.365; P= 0.002). The mean total score was significantly higher for pregnant women than in women with negative pregnancy, 18.27±1.33 versus 16.35±2.47, respectively (P= 0.005). The cutoff value was >17 with an acceptable accuracy level of 74.2. The sensitivity of that cutoff vale was 80 % and the specificity was 65.5%. Uterine artery pulsatility index and total uterine biophysical score are the principal predictors of positive pregnancy outcomes in infertile women undergoing IUI.

Keywords

References

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  20. Guedes-Martins L, Gaio R, Saraiva J, Cerdeira S, Matos L, Silva E, et al. Reference Ranges for Uterine Artery Pulsatility Index during the Menstrual Cycle: A Cross-Sectional Study. Crispi-Brillas F, editor. PLOS ONE. Public Library of Science (PLoS); 2015;10(3):e0119103. Doi: http://dx.doi.org/10.1371/journal.pone .0119103 [PMC][PlosOne] Biography Dr. Rawaa Saad Hasan Abunayla She graduated from Tikrit University, College of Medicine in 1996. Completed permanency in gynecology and Obstetrics in 2002. Received the Diploma in Obstetrics and Gynaecology in 2007 from Baghdad University, College of Medicine. She worked as a senior at Al Rumaitha General Hospital. Currently she is a student in the High Diploma in Clinical Infertility and ARTs in High institute for Infertility Diagnosis and ARTs Al Nahrain University, 2020. Dr. Lubna Amer Al-Anbari She received the M.B.CH.B., the Higher diploma from the college of medicine, University of Baghdad, in 2004, and 2011, respectively. She received the board in infertility from the Iraqi society of medical specialists in 2012. She published many kinds of research both local and international. She supervised many students. She held many academic positions. Dr. Muayad S. Abood He received the M.B.CH.B. from Al-Kufa University, the M.Sc., and the Ph.D. in Pharmacology from Al Nahrain University, in 1998, 2008, and 2014, respectively. He occupied several academic positions including the dean assistant for scientific affairs at Al Nahrain University. He has more than 10 published papers both local and international. Dr. Huda A. R. Hussaini She received the M.B.Ch.B: Babylon University, college of medicine, in 2000. The diploma in Radiology from the University of Baghdad in 2007. She is a fellow of the Iraqi Board for Medical Specialization, Council of Radiology since 2008. Currently, she is an assistant professor. Al Nahrain University, College of Medicine, department of surgery ( specialist radiologist ). She is a Member of staff in the high Institute of infertility diagnosis and ARTS. Including the ultrasound department in the institute since 2018. She has Participations in a lot of annual meetings, medical conferences. Seminars, continuous learning, and thesis discussion. She is a member of the Iraqi medical association, the Iraqi Society of radiologist and medical imaging, Iraqi Journal of Embryos infertility researches, European Society for Hybrid, Molecular, and translation imaging. She published more than articles and has supervised many students. How to cite: Abunayla RSH, Al-Anbari LA, Abood MS, Hussaini HAR. Using Uterine Biophysical Profile as a Predictor of Endometrial Receptivity and Pregnancy in Stimulated IUI cycles; Iraqi Journal of Embryos and Infertility Researches (IJEIR), (2019); 9(2): 78-94. Doi: http://doi.org/10.28969/IJEIR.v9.i2.r6 © 2019 Author(s)